RNA Therapy

RNA Therapy

Ribonucleic Acid Injections

Every disturbance of the cell metabolism leads to premature aging processes, often accompanied by a loss of the body’s own nucleic acids. The therapy with nucleic acids from various organs links in a particular way the treatment with “orthomolecular substances”, i.e. the addition of the body’s own substances, with “organotherapy”, during which the cell-specific substance and information is made available.

Chronic and degenerative diseases with disturbed cell metabolism can be treated in a targeted manner through the support of the body’s own regeneration capabilities and targeted stimulation of newly introduced mesenchymal stem cells with such organ extracts.

Consequently, organ extracts containing nucleic acids can be essential building blocks for a holistic, regenerative treatment.

RNA Therapy:

Nucleic acids can be administered in various approaches. The nucleic acids are distributed rapidly throughout the body, irrespective of the type of administration. They can also penetrate the mucous membranes and overcome the blood-brain barrier. The liver and kidneys have the highest uptake rate for nucleic acids.

An active and a passive process are assumed for the resorption of the oligonucleotides (short DNA or RNA molecules). The oligonucleotides taken up by the cells can be found in both the cytoplasm and the cell nucleus.

Effects

In the following text, examples from the multitude of international publications have been chosen.

DNA synthesis

As RNA-oligomeres are directly involved as primers during the initiation of DNA-synthesis, DNA-synthesis can be influenced by the exogenous RNA. This has been confirmed by in vitro and in vivo experiments by a number of working groups. A stimulating effect of exogenous RNA on DNA-synthesis was also shown in experiments by Lodemann et al using an in vitro DNA- synthesizing system.

RNA synthesis

RNA-synthesis (transcription) occurs on various selected points of the DNA, depending on the cell type. The transfer of the information stored in the DNA- nucleotide sequence into the sequence of the single-stranded RNA occurs using various enzymes, which catalyse the synthesis of different RNA types (e.g. ribosomal RNA [rRNA], messenger RNA [mRNA], transfer RNA [tRNA] and short-chain nuclear RNA [snRNA]). The direct stimulating influence of exogenous RNA on RNA synthesis has been demonstrated in several experiments. 

Protein biosynthesis

Protein synthesis takes place in the cytoplasm on the ribosomes. These represent multi-enzyme complexes, which catalyse the very complex processes of the exact transfer of the mRNA linear nucleotide sequence into the protein amino-acid sequence (translation). Each of the around 20 naturally occurring L- amino acids, from which the proteins are made, is determined by a sequence of three nucleotides.

There are vast numbers of experiments into the influence of exogenous RNA in translation, which partly have been performed in cell-free systems and partly in cell cultures. The changes in protein synthesis are usually detected autoradiographically, by the determination of incorporated radioactively- marked amino acids.

All the experimental results from the international literature regarding the influence of exogenous RNA on protein biosynthesis can be basically summarised in three conclusions:

  1. Protein synthesis can be stimulated by external supply of both complete RNA and of individual fractions of differing chain lengths.

2. The supply of exogenous RNA develops its effect both in cell-free systems as well as in cell cultures and living organisms, which demonstrates that the externally added RNA is taken up by intact cells.

3. For the strength of the effectivity of the exogenous RNA, the origin regarding the “organ proximity” and the relationship of the species play a significant role, whereby clearly organ specificity is most important specificity.

Regulation of cell differentiation

The cells of a higher organism differ greatly from each other in their morphology and physiology, although the DNA in all the cells is the same. Cell differentiation occurs by the differing selection of the DNA sections necessary for protein synthesis. From what is known today, a very important part of the control of gene expression is at the transcription level.

Hormone-like effects

The hormone-like effects of exogenous RNA, or its stimulatory effects on the endocrine system, can be traced back to the organ-specific stimulation of protein synthesis of the affected glands.

Summary

The versatile therapeutic application possibilities of oligonucleotides are based on their polyvalent spectrum of activity and their ability to physiologically modulate the metabolism and the immune system of an organism on various functional levels. In every tissue the structurally different oligonucleotides determine the biosynthesis of the organspecific proteins.

Besides central importance in the biosynthesis of proteins, oligonucleotides have additional, multiple functions, which contribute to the maintenance of physiological cell regulation and function. Furthermore, they are thus also able to influence by regulation, for example, DNA synthesis, cell differentiation and immune procedures.

In further independently from each other performed studies, it has been shown that the effect is organ specific and that organ specificity is more important than species specificity.

The influence of oligonucleotides on the various processes of the metabolism leads as a whole to a more rapid stimulation of the reduced functional cell activity as well as to a reinforcement of the regeneration and restoration of damaged tissue.

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